Short c-vitae: Dr. Jeroen Kool is an analytical chemist with research interests in high resolution screening of biologically active compounds. During his PhD study (2001-2005) at Vrije University Amsterdam (VU University), he focused on the integration of chemical - with biochemical detection after separation methodologies. There, he worked on proteomics (biomarker discovery) focusing on complex regional pain syndrome. He is also an assistant professor at the Division of Biomolecular Analysis at VU University, where he is responsible for the research line named Bioactivity Screening Methodologies. His research achievements allow full compatibility of analytical separations with biological assays (including cellular) and parallel MS detection for investigation of bioactive mixtures (metabolic mixtures, venoms, natural extracts) using miniaturized setups and nanospotting technologies.

Dr. Jeroen Kool developed hyphenated analytics for both LC and GC separations to bioassays for identification of biologically active toxicants in natural extracts, food and the environment. In case of GC fractionations, we developed and patented an automated system for high resolution fractionation of complete GC chromatograms with parallel chemical detection, such as FID and MS. Dr. Kool also developed analytical methodologies for bioactivity profiling of metabolic mixtures from drugs and lead compounds targeting GPCRs, nuclear receptors, protein kinases and ion channels. Currently, we are working on post-column microfluidics and nanospotting analytics for analysis of bioactive mixtures only available in low amounts. Insect and animal venoms are examples that contain many different, highly potent, and sometimes very selective peptide ligands for a large variety of medicinal targets. Recently, his group started developing and applying analytics for characterization of venom induced pathologies in order to better understand snakebite envenoming and as such develop better treatment strategies based on antivenom & small molecular drugs.

https://www.scopus.com/authid/detail.uri?authorId=8953804700

h-index: 21                                                       Documents by author: more than 93

Important publications:

1. Dina Lakayan, Jussipekka Tuppurainen, Teemu Eemeli Suutari, Dick J. van Iperen, Govert W. Somsen, Jeroen Kool, Design and evaluation of a multiplexed angular-scanning surface plasmon resonance system employing line-laser optics and CCD detection in combination with multi-ligand sensor chips, Sensors and Actuators B: Chemical, Volume 282, March 2019, Pages 243-250.

2. Barbara M. Zietek, Ynze Mengerink, Jan Jordens, Govert W. Somsen, Jeroen Kool, Maarten Honing, Adduct-ion formation in trapped ion mobility spectrometry as a potential tool for studying molecular structures and conformations, International Journal for Ion Mobility Spectrometry, Volume 21, June 2018, Pages 19–32.

3. Elena Domínguez-Vega, Rob Haselberg, Dick van Iperen, Jeroen Kool, Govert W. Somsen, Gerhardus J. de Jong, Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components, Sensors and Actuators B: Chemical, Volume 254, January 2018, Pages 1040-1047.